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15 L Bioreactor for Cell Cultivation

15 L Bioreactor for Cell Cultivation

Novel magnetically coupled drive: eliminates the risk of contamination within the vessel since there is no mechanical seal.

Autoclavable sampling port: The sterilisable port facilitates operational activities.

Mixing and aeration: tailored for cell cultivation (plant and mammalian cells).

Uniform lid construction: No welded components within the lid for easy maintenance and sterility.

Flexible working volume: 15 L bioreactor with working volume up to 11 L.

Product Description

Our 15 L autoclavable bioreactor is designed for cell cultivation and is ideal for use within R&D and process development. The borosilicate glass vessel is mounted between a jacketed base and a non-welded lid.

The uniform lid features all the necessary ports and sensors that might be required for bioprocesses and features a convenient carrying handle. Featuring twelve ports comprising of five ports for sensor connections, three ports for bioreactor’s liquid supply, two ports for gas sparger and gas output and two spare ports that can be user defined.

There is a sterilisable sampling port conveniently located in the base of the vessel to facilitate operational activities during a process. The overall design of the reactor is simple to maintain and apply basic operations and processes.

The magnetically coupled drive which can reach up to 700 rpm ensures excellent sterility within the vessel throughout fermentation.

The bioreactor process control ensures:

Temperature (the temperature sensor (Pt100) is located in the bioreactor tank) regulation. Carried out by supplying a control signal either to the heating element or the electro-magnetic cooling water valve of the thermostat. Thermoregulation is carried out by circulation of thermostated water through the bioreactor’s jacket, which is located in the bottom lid of the vessel;

pH control. Carried out by supplying base or acid solutions to the bioreactors medium using the bioprocess controller’s peristaltic pumps;

pO2 control. Ensured by automatic adjustments of the stirrer’s rotational speed. The actual pO2 value is monitored using a pO2 electrode;

Foam control. Carried out by supplying an antifoam agent to the bioreactor’s medium using the bioprocess controller’s peristaltic pumps. The foam level is monitored using a conductivity sensor;

Feeding (of a substrate). Carried out using the bioprocess controller’s peristaltic pump and the respective feeding rate/volume is controlled by the feeding profile, which is set in the bioprocess controller;

Level control. Carried out using the bioprocess controller’s peristaltic pump. The medium level is monitored using a conductivity sensor;

Mixing. Ensured by a magnetic drive (stirrer inner shaft and impellers contain magnets), the agitator is driven by a motor which is mounted on the top lid of the bioreactor.

Options

Bioreactor Product Option
15 L Bioreactor for Cell Cultivation Optical density sensor with ARC view 265 transmitter and accessories (Hamilton)
Viable cell density sensor with ARC view 265 transmitter and accessories (Hamilton)
Methanol/ethanol gas sensor (BlueSens)
Methanol/ethanol immersed sensor (Raven Biotech)
Overpressure sensor, autoclavable, 0-1 bar, measuring accuracy +/- 0.02 bar
Overpressure control, 0-1 bar, control accuracy +/- 0.0 bar.
O2/CO2 analyzer BlueInOne Ferm (BlueSens), including flow adapter
Mass flow controller for air
Mass flow controller for O2
Volumetric oxygen mass transfer coefficient kLa, Oxygen uptake rate OUR, CO2 exchange rate CER (includes overpressure sensor and O2/CO2 analyzer)
Rushton turbine set with bushings
Microsparger
Factory accepted test FAT
SCADA for monitoring, control and reporting according the requirements of 21 CFR Part 11

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